However, the variable responses of patients with MLL-r in this trial underscore the need for additional mechanistic insights into functional regions of DOT1L to improve therapeutic efficacy and trial designs for DOT1L-targeted therapy. A selective DOT1L inhibitor, EPZ5676 (Pinometostat) 21, has demonstrated proof-of-principle clinical benefits via induction of differentiation of MLL-r leukemic cells in a phase I clinical trial 22. Recent achievements in cancer epigenetics include discovery of a central role for the H3K79 methyltransferase DOT1L in maintaining MLL-r leukemia, an aggressive malignancy recognized in 5–10% of human acute leukemia cases 19, 20. Furthermore, we couple the sc-Tiling with three-dimensional structural modeling and discovered a previously unrecognized self-regulatory domain in DOT1L that modulates the chromatin interaction, enzymatic activation, and therapeutic sensitivity in MLL-r leukemia. In this study, we develop a single-cell CRISPR gene tiling pipeline “sc-Tiling” to provide high-resolution transcriptomic profiling of the coding regions of histone H3 lysine 79 (H3K79) methyltransferase DOT1L, an epigenetic therapeutic candidate selectively essential to mixed-lineage leukemia gene-rearranged ( MLL-r) leukemia 17, 18, 19. Nevertheless, the potential of single-cell CRISPR screen technology to examine the gene function at a sub-gene resolution has not been fully explored. The current single-cell CRISPR screens focused on observing single-gene function, gene-to-gene interaction, and enhancer-to-gene regulation 10, 12, 13, 14, 15, 16. Recent breakthroughs in combining the CRISPR library screens with droplet RNA-sequencing (RNA-seq) platforms demonstrated the capacity of monitoring the gene expression changes upon genetic perturbations in single cells (e.g., Perturb-seq, CRISP-seq, CROP-seq) 8, 9, 10, 11. However, the traditional CRISPR dropout/enrichment screens restricted the application to investigate functional elements associated with cell survival phenotypes. Furthermore, high-density CRISPR targeting of coding exons has been demonstrated to identify functional domains in genes 3, 4, 5, 6, 7. The integration of CRISPR (clustered, regularly interspaced, short palindromic repeats) with next-generation sequencing technology for high-throughput genetic screens is a powerful tool for discovering functional genes in various pathways and cellular contexts 1, 2. Distinct from other reported single-cell CRISPR screens focused on observing gene function and gene-to-gene/enhancer-to-gene regulation, sc-Tiling enables the capacity to identify regulatory mechanisms within a gene-coding region that dictate gene activity and therapeutic response. Here, we present “sc-Tiling,” which integrates a CRISPR gene-tiling screen with single-cell transcriptomic and protein structural analyses. Furthermore, breakthroughs in combining CRISPR library screens with single-cell droplet RNA sequencing (sc-RNAseq) platforms have revealed the capacity to monitor gene expression changes upon genetic perturbations at single-cell resolution. Recently, high-density mutagenesis via CRISPR tiling of gene-coding exons has been demonstrated to identify functional regions in genes. To date, CRISPR gene editing has primarily been applied to defining the role of individual genes. Identification of novel functional domains and characterization of detailed regulatory mechanisms in cancer-driving genes is critical for advanced cancer therapy.
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Maybe you could go for something a little less… intense. Torchlight III on the Switch could have been a solid light-ARGP to waste a few hours on, but it was pushed out of the nest too soon. I don’t know that they all hit the same way, but I imagine plenty of folks are preoccupied with Pillars of Eternity or Diablo II: Resurrected. I would not recommend Torchlight III at full price, but for $10? Now that the dust has settled, I think a case could be made - just don’t expect it to be “Torchlight II but bigger and better.” It’s pretty simple, which can be good or bad depending on your tastes and what kind of gaming mood you’re in. One final piece of advice: when facing bosses or other powerful. If something does not fit with the build, it is possible to respec skills, using those points elsewhere. This guide will get new players started, but they will have to experiment with what works for them. There is cross play between the microsoft store version (not steam) and the xbox version, they do it with lots of games that have 'no crossplay' because if people cant figure it out yet all an xbox is is a windows ten device that does less. One potentially huge caveat with this series that I’ve had to double-check before in my routine couch co-op game searches: Torchlight II and III only have online co-op. Torchlight 3 is Early Access now, which means much can and will change. Was this Diablo-like RPG worth the long wait Let’s set things up and give out some tips. You’re probably “good” on the original game and its fan-favorite sequel after years of discounts and giveaways, but if you still need to get Torchlight II on Switch specifically, or you have been on the fence with Torchlight III at higher prices, here you go. It’s been eight long years since a new Torchlight game was released, although last year the second game finally made it to modern consoles, including the Nintendo Switch. Torchlight III - $9.99 on Steam and Nintendo Switch.Torchlight II - $5.99 on Steam and Nintendo Switch Update: Torchlight III 's Switch launch has been confirmed for Thursday 22nd October, just over a week after the action-RPG's launch on other consoles good news for fans who may have been. 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Tekken 7 Tekken 6 Monaco Lili Hikari Kujo, tekken, video Game, fictional Character, girl png 1600x5159px 4.94MB.Tekken 5: Dark Resurrection Tekken 6 Tekken 4 Tekken Tag Tournament 2, Le Monde De Lili, video Game, fictional Character, tekken 6 Bloodline Rebellion png 613x1120px 526.83KB.Tekken 5: Dark Resurrection Lili Tekken 7 Video game, tekken, game, cg Artwork, black Hair png 1024x1448px 1.02MB.Tekken 7 Tekken 6 Tekken 5 Ling Xiaoyu Street Fighter X Tekken, Tekken Lili, purple, violet, video Game png 564x1033px 517.03KB. Unsourced material may be challenged and removed. Please help improve this article by adding citations to reliable sources in this section. This section needs additional citations for verification. The hydrated salt can be dried for re-use but will dissolve in its own water of hydration if heated quickly and form a hard amalgamated solid when cooled. Anhydrous calcium chloride has been approved by the FDA as a packaging aid to ensure dryness (CPG 7117.02). Kelp is dried with calcium chloride for use in producing sodium carbonate. Laboratory and related drying operations ĭrying tubes are frequently packed with calcium chloride. It is added before the coagulant.Ĭalcium chloride is used to prevent cork spot and bitter pit on apples by spraying on the tree during the late growing season. In cheesemaking, calcium chloride is sometimes added to processed (pasteurized/homogenized) milk to restore the natural balance between calcium and protein in casein. It affects flavor and chemical reactions during the brewing process, and can also affect yeast function during fermentation. In brewing beer, calcium chloride is sometimes used to correct mineral deficiencies in the brewing water. Also, it is frequently added to sliced apples to maintain texture. Calcium chloride's freezing-point depression properties are used to slow the freezing of the caramel in caramel-filled chocolate bars. The extremely salty taste of calcium chloride is used to flavor pickles without increasing the food's sodium content. It is commonly used as an electrolyte in sports drinks and other beverages, including bottled water. Īs a firming agent, calcium chloride is used in canned vegetables, in firming soybean curds into tofu and in producing a caviar substitute from vegetable or fruit juices. Its use in organic crop production is generally prohibited under the US National Organic Program. It is considered as generally recognized as safe (GRAS) by the U.S. Calcium chloride is permitted as a food additive in the European Union for use as a sequestrant and firming agent with the E number E509. The average intake of calcium chloride as food additives has been estimated to be 160–345 mg/day. Using calcium chloride reduces the need for grading by as much as 50% and the need for fill-in materials as much as 80%. If these are allowed to blow away, the large aggregate begins to shift around and the road breaks down. It keeps the finer dust particles on the road, providing a cushioning layer. A concentrated solution keeps a liquid layer on the surface of dirt roads, which suppresses the formation of dust. The second largest application of calcium chloride exploits its hygroscopic nature and the tackiness of its hydrates calcium chloride is highly hygroscopic and its hydration is an exothermic process. Calcium chloride was sprayed on this road to prevent weathering, giving it a wet appearance even in dry weather. We honestly don't know why there aren't more 16:18 monitors for coders, writers, and other multitaskers. And, we're happy to report that its performance is just as exceptional in practice, giving us those rich, sharp, vibrant visuals we expect from displays at this price range. That should effortlessly connect you with clients, project managers, and other colleagues whether you're based at home full-time or following a hybrid model.ĭespite not having fully reviewed it yet, we have utilized it in testing and put it through its paces. All those should make up for the lack of portrait mode.Īs we now live in a world where working from home or remotely is the norm, its best feature is that built-in intelligent webcam that delivers up to 4K at 30 fps or 1080p at 60fps video and comes with a SafeShutter feature. Several highly accurate creative colour modes are on hand as well for your projects that might involve graphics, images, or videos. That means that it comes loaded with multitasking features that programmers will certainly appreciate, including auto KVM (Keyboard, Mouse, Video), Picture-by-Picture (PbP) and Picture-in-Picture (PiP), and the ability to daisy chain two 4K monitors. The Dell UltraSharp U3223QZ is made specifically for productivity and multitasking. See our full BenQ PD322OU review for more details. We find 4K resolution on a 32-inch panel with a 140 PPI pixel density to be the sweet spot for delivering sharp, highly-detailed visuals, which can make for a comfortable coding experience and serve for a lot more besides. More importantly for programmers and web designers, it boasts features like PiP/PbP for multi-input multitasking, two Thunderbolt 3 ports for daisy-chaining multiple monitors and even connecting external GPUs, and that coder-coveted portrait mode, which comes with auto-portrait desktop orientation. And its current retail price is around $1,099. It's factory calibrated and delivers high colour accuracy out of the box, it comes with a variety of colour modes Animation, Rec.709, Adobe RGB, and CAD/CAM to help simplify creative workflows. It boasts excellent colour coverage with 100% Rec.709, 100% sRGB, and 95% P3 colour gamuts – although our own tests recorded up to 98% DCI-P3. The BenQ DesignVue PD3220U is an outstanding monitor. To keep the price down, the ViewSonic VP2458 Professional keeps things to a humble HD resolution, but that's a fair compromise for this price. On top of that, the near-frameless design offers a seamless visual experience when using multi-monitor setups if you want to go down that avenue. The 24in panel makes it a good size to fit in a dorm or small apartment setup while an adjustable setup allows you to work in the best posture even if you’re in a tight space. It also delivers lifelike colours with its 100% sRGB coverage and quick and easy colour calibration. It comes with the kind of blue light filter offered by pricier monitors so you can reduce eyestrain even if you’re on an all-nighter to make a deadline. At under $300/£300, it falls within most people's budget, but it still offers some attractive features for programmers. Fortunately, there are a few good affordable options out there, including the VP2458 Professional from ViewSonic. If you're new to programming or still studying, then you'll probably want a monitor for programming that's kinder on your bank account, but ideally without sacrificing quality. So far, they’ve sent their radar out to the field three times: Once to look at the Briceburg Fire that flared up near Yosemite National Park toward the beginning of the month, and twice to study the Kincade Fire that roared to life in Northern California’s Sonoma County last week. Forest Service had planned to set in southern Utah at the end of the month or in early November.īut when fires started erupting across California in early October, Clements and his team mobilized. Originally, SJSU scientists were going to deploy the radar for the first time to study a large, controlled burn that the U.S. Disaster Preparedness Guide: Tornadoes “ To visualize how much of a leap in resolution the new tool represents, Lareau made the analogy to images of Pluto captured before and after NASA’s 2015 New Horizons flyby mission. “It’s night and day,” says Neil Lareau, a fire weather researcher at the University of Nevada, Reno who helped put together a proposal for this radar system while he was a professor at SJSU. This could lead to better tools for tracking and forecasting fires, thereby reducing damage and casualties.Īnd because the radar is mounted on a truck, the scientists working with the Fire Weather Research Laboratory can bring it out to an active fire and start collecting information within minutes of arriving on the scene. Researchers hope the system will yield new insights into the inner structure and evolution of the most dangerous blazes. Disaster Preparedness Guide: Earthquakes “ Scientists with San Jose State University’s Fire Weather Research Laboratory have been deploying to the blazes, taking advantage of the dire fire weather to test an experimental Doppler radar capable of peering into wildfire smoke plumes at unprecedented resolution. Fierce, fast-moving wildfires exploded up and down the state during October, prompting utilities to shut off power to millions and forcing hundreds of thousands to evacuate.īut while tens of thousands fled the flames, there are a handful of researchers who have driven towards them. California has been caught in the midst of a fiery assault fueled by historically powerful winds, humidity levels stuck in the single digits, and the effects of long-term climate change. Asymmetric diffraction can be generated in these gratings, and the +1st order transmitted wave is suppressed completely at the diffraction vanishing point (DVP). It is shown that the model describes the edge diffraction reasonably well in predicting the diffraction as a function of scattering angle, edge thickness, and frequency. Diffraction involves the bending or spreading out of a sound wave in a single medium, in which the speed of sound is constant. The method of rigorous coupled-wave analysis (RCWA) is developed to analyze the diffraction properties of acoustic parity-time-symmetric gratings. 8 Another way is to use phased arrays of transducers operated at a fixed frequency (typically 40 kHz), which can tailor the. To improve the simulating accuracy for multiple diffractions, a multiple acoustic diffraction simulating method based on ray iteration tracing is proposed in this paper. The theory is incorporated into the deformed edge solution to model the diffraction by a disk of finite thickness, and is compared with laboratory experiments of backscattering by elastic disks of various thicknesses and by a hard strip. One of the simplest approaches is to use a single transducer and a reflector to generate standing waves along one spatial dimension (1D) 7 or multiple faced transducers to produce 2D standing waves with orientation control. The model accounts for all orders of diffraction and is valid for all kw, where k is the acoustic wave number and w is the width of the midplanar segment and reduces to the solution of diffraction by a single knife edge as w→0. The solution is an extension of the asymptotic formulas for the double-edge second-order diffraction via amplitude and phase matching given by Pierce. Experimental observation of acoustic sub-harmonic diffraction by a grating Full Record Related Research Abstract A diffraction grating is a spatial filter causing sound waves or optical waves to reflect in directions determined by the frequency of the waves and the period of the grating. Acoustic diffraction from a semi-infinite elastic plate under arbitrary fluid loading with application to scattering from Arctic ice leads 1989 Access the. Researchers are especially interested in the phenomenon of sound diffraction by spheres and cylinders because of the relatively simple mathematical models that can be derived. A cw solution of acoustic diffraction by a three-sided semi-infinite barrier or a double edge, where the width of the midplanar segment is finite and cannot be ignored, involving all orders of diffraction is presented. The problem of acoustic diffraction by an object has attracted the attention of researchers since the late 19th century. Peckel Möller in his 1895 monograph Cod Liver Oil and Chemistry, “cod-liver oil was not a desirable article of consumption indeed, to put the matter plainly, it was an abomination, and no one could have taken it willingly, even once, not to speak of day after day and month after month. The oil grew darker during the rotting process, resulting in three grades: pale, light brown, and dark brown. Fishermen often applied heat to extract the last bits of oil from the smelly, decaying mass. Its manufacture was simple: cut out the fish livers (with gallbladders), throw them into barrels, and let them decompose. Northern European fishing communities used cod-liver oil for generations to restore health and alleviate aches and pains before the doctors and chemists of 19th-century Europe began to take an interest. National Museum of American History Collections, Smithsonian Institution A “Highly Disagreeable Remedy” The man with the fish endures today, a testament to the persistence of an age-old tradition, even as scientific and commercial interest in cod-liver oil has waxed and waned. His image was engraved and embossed on countless boxes and bottles of a cod-liver-oil preparation printed in full color on advertising trade cards, booklets, and posters distributed around the globe and in one instance painted several stories high on the side of a building in lower Manhattan. The man has few identifying features, but the words “SCOTT’S EMULSION” appear along the hem of his jacket.īy 1900 “the man with the fish” was famous. A common codfish, the Gadus morhua is recognizable by the brown and amber spots on its body, the light stripe down its side, and the three dorsal fins. A thick rope, wrapped around his waist, shoulders, and hands, secures the load on his back-a huge fish with gaping mouth and glassy yellow eye, its tail sweeping the ground. The man stoops forward, glances out from under the brim of his hat, legs braced under the weight of his load. Suppress pop-up ads in Safari with Glimmerblocker | Daily. 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Sometimes, your Maxthon account and UID are also needed.Īs usual, if you have any question or suggestion, comment here directly, or go to our Facebook or Twitter page to share with us your questions or suggestions.We will forward it to engineers for analysis. Maxthon Crash report, which you could get by pressing “Win + R” keyboard > run “%temp%” > press “Enter” > find the folder “MaxthonCrashData”.Ĭompress the whole folder and send it to us.Microsoft Edge in 2023 by cost, reviews, features, integrations, deployment, target market, support options, trial offers, training options, years in business, region, and more using the chart below. Security software installed on your computer Microsoft Edge What’s the difference between Maxthon and Microsoft Edge Compare Maxthon vs.Your Operating System, and device RAM information.You may be required to send the following information to them to help identify the problem more effectively: Our engineers are glad to analyze your problems and help fix them. In this case, you need close some programs or overloaded websites.Ībove are some common reasons for the crash during the use of Maxthon, which you can check by yourself to identify the cause, but if all above solutions don’t work for your situation, you can contact Maxthon support team for more help. Available for Android, Chrome, Firefox, Internet Explorer, Maxthon, Opera, Safari and Yandex, Adblock Plus uses filters that you choose to block all. This is also a common reason for the crash, but it’s not hard for users to realize that because it usually happens when you open too many tabs, apps or some tabs and apps are consuming large proportion of your computer RAM. To solve this problem, you can disable Magic Fill feature from Menu > Settings > Magic Fill Settings > Do not enable.Īfter checking that, refresh the problematic page, everything will come back to normal. Magic Fill helps you fill information automatically, but sometimes it is applied to pages that shouldn’t be. So sometimes if you encounter crash during browsing, you can try disabling Adblock Plus to see whether it is fixed.Ĭrashing caused by Magic Fill often appears when the web page freezes, especially when there’s no problem when you are browsing other pages. However, some custom rules may cause incompatibilities with the browser, thus causing the crash. Your feedback is also appreciated if you could identify problematic add-ons causing crashes.Īdblock Plus is a powerful feature in Maxthon browser, with which you can not only filter ads but customize your filter rules. To avoid that, you don’t need to uninstall all add-ons, but uncheck some less commonly used add-ons from Menu > Settings > Functions & Add-ons tab. Maxthon is a powerful browser which allows you to install as many add-ons as you want, but too many add-ons especially some low-quality add-ons may cause some problems. Too many add-ons, or add-ons of low quality.If Maxthon5 closes suddenly during your browsing, you can check whether it’s because of the following reasons: But actually I’d rather you never use those tips (after all Maxthon is one of the most stable browsers)! You might be as surprised as I was.Hi Maxers, remember our last post about browser startup crash? Hope it was helpful to you. We hope Maxthon Cloud Browser could help more and more people enjoy the Internet, while saving more data and money. If you are an Internet Explorer user who wants more options, however, or are just interested in life beyond Mozilla, give Maxthon a try. Millions of people use Maxthon browsers to watch videos, connect with friends, search on the web, and sync data across platforms. store of Maxthon also includes many popular Chrome extensions like Adblock. If you like a simple browsing experience, or are a big fan of your Firefox add-ons, Maxthon probably isn't for you (although there are a good selection of Maxthon add-ons). Here we have shared the latest version of Maxthon 6 Cloud browser offline. It would take a very long time to detail all of Maxthon's options, so suffice to say that as well as the standard ones (tab behavior, display, encoding), there are a multitude of other features, from content control to image and script disabling, an in-built ad-blocker, auto form-filler and advanced screenshot function.In fact, some of the options are quite complex, and you might want to take a look at the user manual before jumping straight in. If things are beginning to sound a bit crowded, you can disable most, leaving the whole Maxthon interface much cleaner. These options, including the standard File, View, and Tools types, can be found in the Menu Bar, while there are even more in the lower Status bar. This means they are easy to see and modify, which is just as well, as there are so many of them. Maxthon generally opens its configuration options in new tabs, rather than windows. |